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KMID : 0365819700100010087
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Journal of Pusan Medical College
1970 Volume.10 No. 1 p.87 ~ p.96
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Effects of Tetracycline on Lipid Concentrations of Serum, Liver, and Aorta in Rabbits Fed with Cholesterol Diet
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Abstract
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This study was undertaken to determine the effect of tetracycline on lipid concentrations of serum, liver and aorta in rabbits fed with cholesterol diet.
Six groups of rabbits were fed with diets composed of basic diet alone, basic diet plus tetracycline, basic diet plus cholesterol, and basic diet plus cholesterol plus tetracycline, during which_ time free cholesterol and it´s esterified form, triglycerides, and phospholipids were analyzed biweekly. After termination of experiment, the aortic intima was graded for atheromatous changes, and the lipid levels of the liver and the aorta were determined with following results:
1. The serum lipid levels in the groups fed with basic diet containing tetracycline showed no significant changes through the entire experimental period as compared with those fed with basic diet alone.
2. The serum lipid levels in the groups fed with diets containing cholesterol showed a linear increase. The serum lipid levels in the groups fed with cholesterol plus tetracycline were lower than the groups fed with diets containing cholesterol alone. Of the cholesterol fed groups the lowest serum level was found in the group administered with 200 mg/day of tetracycline.
3. Triglycerides and phospolipids level in the liver and the aorta revealed no noticeable difference between the group fed with basic diet alone and those fed with basic diet plus tetracycline. In both the group fed with basic diet containing cholesterol and the groups fed with basic diet plus cholesterol plus tetracycline, free cholesterol and it´s esterified form were incresed, especially in the former group.
4. The group fed with cholesterol diet plus 200 mg/day tetracycline showed atheromatous change involving 23. 8±2. 8% of the entire intimal area of the aorta, while the group fed on cholesterol diet plus 100 mg/day tetracycline and that on cholesterol alone had atheromatous involvement of 41.4±6.9% and 47.2±5.6% respectively.
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KEYWORD
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